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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14045 | Leukotriene B4 | LTB4,5(S),12(R)-DiHETE | Others |
Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
T37619 | Leukotriene B4 Ethanolamide | ||
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this recept... | |||
T37618 | Leukotriene B4 dimethyl amide | Leukotriene B4 dimethyl amide | |
LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on gui... | |||
T37260 | 14,15-dehydro Leukotriene B4 | 14,15-dehydro Leukotriene B4 | |
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement ... | |||
T37256 | 12-oxo Leukotriene B4 | 12-oxo Leukotriene B4 | |
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosom... | |||
T37970 | 12-epi Leukotriene B4 | 12-epi Leukotriene B4 | |
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis pr... | |||
T38087 | 20-hydroxy Leukotriene B4 | 20-hydroxy Leukotriene B4 | |
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing deg... | |||
T73793 | 20-Carboxy-Leukotriene B4 | ||
20-Carboxy-Leukotriene B4 (20-COOH LTB4), a metabolite of Leukotriene B4 (LTB4), exhibits high affinity binding to the BLT1 receptor. It notably inhibits LTB4-mediated neutrophil responses, including migration, degranula... | |||
T72144 | 6-trans-12-epi-Leukotriene B4 | ||
6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent. | |||
T21504 | γ-Linolenic Acid methyl ester | Methyl gamma-linolenate | LTR |
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist. | |||
T15002 | CP-105696 | Pfizer 105696 | LTR |
CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist for the study of allograft rejection. | |||
T77638 | BIRM 271 | Phospholipase , LTR | |
BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu... | |||
T3715 | Acebilustat | CTX-4430 | Aminopeptidase , LTR |
Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor. | |||
T17191 | Bunaprolast | U66858 | Lipoxygenase , LTR |
Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2 release. | |||
T22946 | LY255283 | LY 255283 | Leukotriene Receptor |
LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A2318... | |||
T68119 | Ontazolast | BIRM-270 | LTR |
Ontazolast is a small molecule leukotriene B4 receptor (LTB4R) antagonist for the treatment of immune system disorders and respiratory diseases.Ontazolast is a candidate compound for the treatment of asthma. | |||
T68108L | Moxilubant HCl | Moxilubant hcl(146978-48-5 Free base) | LTR |
Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid art... | |||
T28974 | Ticolubant | Calcium Channel , LTR | |
Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inf... | |||
T9878 | Croconazole | Lipoxygenase , LTR | |
Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno... | |||
T22358 | Etalocib | LY293111,VML295 | Apoptosis , Leukotriene Receptor , LTR |
Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-l... |